The OPTIMIZE trial: Rationale and design of a randomized controlled trial of motivational enhancement therapy to improve adherence to statin medication

Can-Change members Drs. Kim Lavoie and Tavis Campbell contributed to this manuscript which describes the rational and design of a randomized controlled trial testing the efficacy of motivational interviewing (MInt) in improving adherence to statin medication. The primary outcome is change in MPR adherence to statin medication from baseline to 12-months. Secondary outcomes include within-patient change in self-reported medication adherence, stage of change and self-efficacy for medication adherence, motivation to adhere to statin medication, and lipid profile.